MMP-12 Deficiency Attenuates Angiotensin II-Induced Vascular Injury, M2 Macrophage Accumulation, and Skin and Heart Fibrosis

MMP-12, a macrophage-secreted elastase, is elevated in fibrotic diseases, including systemic sclerosis (SSc) and correlates with vasculopathy and fibrosis. The goal of this study was to investigate the role of MMP-12 in cardiac and cutaneous fibrosis induced by angiotensin II infusion. Ang II-induce...

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Detalles Bibliográficos
Autores principales: Stawski, Lukasz, Haines, Paul, Fine, Alan, Rudnicka, Lidia, Trojanowska, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4193823/
https://www.ncbi.nlm.nih.gov/pubmed/25302498
http://dx.doi.org/10.1371/journal.pone.0109763

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4193823/
https://www.ncbi.nlm.nih.gov/pubmed/25302498
http://dx.doi.org/10.1371/journal.pone.0109763

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