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Valproic Acid and Fatalities in Children: A Review of Individual Case Safety Reports in VigiBase

INTRODUCTION: Valproic acid is an effective first line drug for the treatment of epilepsy. Hepatotoxicity is a rare and potentially fatal adverse reaction for this medicine. OBJECTIVE: Firstly to characterise valproic acid reports on children with fatal outcome and secondly to determine reporting ov...

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Detalles Bibliográficos
Autores principales: Star, Kristina, Edwards, I. Ralph, Choonara, Imti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4193865/
https://www.ncbi.nlm.nih.gov/pubmed/25302991
http://dx.doi.org/10.1371/journal.pone.0108970