A Mouse Strain Defective in Both T Cells and NK Cells Has Enhanced Sensitivity to Tumor Induction by Plasmid DNA Expressing Both Activated H-Ras and c-Myc

As part of safety studies to evaluate the risk of residual cellular DNA in vaccines manufactured in tumorigenic cells, we have been developing in vivo assays to detect and quantify the oncogenic activity of DNA. We generated a plasmid expressing both an activated human H-ras gene and murine c-myc ge...

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Detalles Bibliográficos
Autores principales: Sheng-Fowler, Li, Tu, Wei, Fu, Haiqing, Murata, Haruhiko, Lanning, Lynda, Foseh, Gideon, Macauley, Juliete, Blair, Donald, Hughes, Stephen H., Coffin, John M., Lewis, Andrew M., Peden, Keith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4193875/
https://www.ncbi.nlm.nih.gov/pubmed/25302710
http://dx.doi.org/10.1371/journal.pone.0108926

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4193875/
https://www.ncbi.nlm.nih.gov/pubmed/25302710
http://dx.doi.org/10.1371/journal.pone.0108926

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