Genetic and pharmacological evidence that G2019S LRRK2 confers a hyperkinetic phenotype, resistant to motor decline associated with aging

The leucine-rich repeat kinase 2 mutation G2019S in the kinase-domain is the most common genetic cause of Parkinson's disease. To investigate the impact of the G2019S mutation on motor activity in vivo, a longitudinal phenotyping approach was developed in knock-in (KI) mice bearing this kinase-...

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Detalles Bibliográficos
Autores principales: Longo, Francesco, Russo, Isabella, Shimshek, Derya R., Greggio, Elisa, Morari, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4194318/
https://www.ncbi.nlm.nih.gov/pubmed/25107341
http://dx.doi.org/10.1016/j.nbd.2014.07.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4194318/
https://www.ncbi.nlm.nih.gov/pubmed/25107341
http://dx.doi.org/10.1016/j.nbd.2014.07.013

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