High levels of BRC4 induced by a Tet-On 3G system suppress DNA repair and impair cell proliferation in vertebrate cells

Transient induction or suppression of target genes is useful to study the function of toxic or essential genes in cells. Here we apply a Tet-On 3G system to DT40 lymphoma B cell lines, validating it for three different genes. Using this tool, we then show that overexpression of the chicken BRC4 repe...

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Detalles Bibliográficos
Autores principales: Abe, Takuya, Branzei, Dana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4194320/
https://www.ncbi.nlm.nih.gov/pubmed/25218467
http://dx.doi.org/10.1016/j.dnarep.2014.08.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4194320/
https://www.ncbi.nlm.nih.gov/pubmed/25218467
http://dx.doi.org/10.1016/j.dnarep.2014.08.003

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