Long-Term Corticosterone Exposure Decreases Insulin Sensitivity and Induces Depressive-Like Behaviour in the C57BL/6NCrl Mouse

Chronic stress or long-term administration of glucocorticoids disrupts the hypothalamus-pituitary-adrenal system leading to continuous high levels of glucocorticoids and insulin resistance (IR). This pre-diabetic state can eventually develop into type 2 diabetes mellitus and has been associated with...

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Detalles Bibliográficos
Autores principales: van Donkelaar, Eva L., Vaessen, Koen R. D., Pawluski, Jodi L., Sierksma, Annerieke S., Blokland, Arjan, Cañete, Ramón, Steinbusch, Harry W. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195581/
https://www.ncbi.nlm.nih.gov/pubmed/25310187
http://dx.doi.org/10.1371/journal.pone.0106960

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195581/
https://www.ncbi.nlm.nih.gov/pubmed/25310187
http://dx.doi.org/10.1371/journal.pone.0106960

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