Personalized Tacrolimus Dose Requirement by CYP3A5 but Not ABCB1 or ACE Genotyping in Both Recipient and Donor after Pediatric Liver Transplantation

Tacrolimus (TAC) is the backbone of an immunosuppressive drug used in most solid organ transplant recipients. A single nucleotide polymorphism (SNP) at position 6986G>A in CYP3A5 has been notably involved in the pharmacokinetic variability of TAC. It is hypothesized that CYP3A5 genotyping in pati...

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Detalles Bibliográficos
Autores principales: Chen, Yi-kuan, Han, Long-zhi, Xue, Feng, Shen, Cong-huan, Lu, Jun, Yang, Tai-hua, Zhang, Jian-jun, Xia, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195667/
https://www.ncbi.nlm.nih.gov/pubmed/25310192
http://dx.doi.org/10.1371/journal.pone.0109464

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195667/
https://www.ncbi.nlm.nih.gov/pubmed/25310192
http://dx.doi.org/10.1371/journal.pone.0109464

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