Combination of TRAIL with Bortezomib Shifted Apoptotic Signaling from DR4 to DR5 Death Receptor by Selective Internalization and Degradation of DR4

TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) mediates apoptosis in cancer cells through death receptors DR4 and DR5 preferring often one receptor over another in the cells expressing both receptors. Receptor selective mutant variants of TRAIL and agonistic antibodies against DR4 a...

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Detalles Bibliográficos
Autores principales: Bychkov, Maxim L., Gasparian, Marine E., Dolgikh, Dmitry A., Kirpichnikov, Mikhail P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195680/
https://www.ncbi.nlm.nih.gov/pubmed/25310712
http://dx.doi.org/10.1371/journal.pone.0109756

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195680/
https://www.ncbi.nlm.nih.gov/pubmed/25310712
http://dx.doi.org/10.1371/journal.pone.0109756

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