IL1RAPL1 knockout mice show spine density decrease, learning deficiency, hyperactivity and reduced anxiety-like behaviours

IL-1 receptor accessory protein-like 1 (IL1RAPL1) is responsible for nonsyndromic intellectual disability and is associated with autism. IL1RAPL1 mediates excitatory synapse formation through trans-synaptic interaction with PTPδ. Here, we showed that the spine density of cortical neurons was signifi...

Descripción completa

Detalles Bibliográficos
Autores principales: Yasumura, Misato, Yoshida, Tomoyuki, Yamazaki, Maya, Abe, Manabu, Natsume, Rie, Kanno, Kouta, Uemura, Takeshi, Takao, Keizo, Sakimura, Kenji, Kikusui, Takefumi, Miyakawa, Tsuyoshi, Mishina, Masayoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196104/
https://www.ncbi.nlm.nih.gov/pubmed/25312502
http://dx.doi.org/10.1038/srep06613

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196104/
https://www.ncbi.nlm.nih.gov/pubmed/25312502
http://dx.doi.org/10.1038/srep06613

Ejemplares similares