A designed peptide targeting CXCR4 displays anti-acute myelocytic leukemia activity in vitro and in vivo

Leukemia cells highly expressing chemokine receptor CXCR4 can actively response to stroma derived factor 1α (CXCL12), trafficking and homing to the marrow microenvironment, which causes poor prognosis and relapse. Here we demonstrate that a novel designed peptide (E5) targeting CXCR4 inhibits CXCL12...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Xiaojin, Guo, Hua, Yang, Yanlian, Meng, Jie, Liu, Jian, Wang, Chen, Xu, Haiyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196105/
https://www.ncbi.nlm.nih.gov/pubmed/25312253
http://dx.doi.org/10.1038/srep06610

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196105/
https://www.ncbi.nlm.nih.gov/pubmed/25312253
http://dx.doi.org/10.1038/srep06610

Ejemplares similares