Denosumab mimics the natural decoy receptor osteoprotegerin by interacting with its major binding site on RANKL

Bone homeostasis critically relies on the RANKL-RANK-OPG axis which can be targeted by the fully human monoclonal antibody denosumab in conditions with increased bone resporption such as bone metastases. The binding site and therefore the molecular mechanism by which this antibody inhibits RANKL has...

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Detalles Bibliográficos
Autores principales: Schieferdecker, Aneta, Voigt, Mareike, Riecken, Kristoffer, Braig, Friederike, Schinke, Thorsten, Loges, Sonja, Bokemeyer, Carsten, Fehse, Boris, Binder, Mascha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196153/
https://www.ncbi.nlm.nih.gov/pubmed/25138051

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196153/
https://www.ncbi.nlm.nih.gov/pubmed/25138051

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