Fructose-2,6-Bisphosphate synthesis by 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase 4 (PFKFB4) is required for the glycolytic response to hypoxia and tumor growth

Fructose-2,6-bisphosphate (F2,6BP) is a shunt product of glycolysis that allosterically activates 6-phosphofructo-1-kinase (PFK-1) resulting in increased glucose uptake and glycolytic flux to lactate. The F2,6BP concentration is dictated by four bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bis...

Descripción completa

Detalles Bibliográficos
Autores principales: Chesney, Jason, Clark, Jennifer, Klarer, Alden C., Imbert-Fernandez, Yoannis, Lane, Andrew N., Telang, Sucheta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196155/
https://www.ncbi.nlm.nih.gov/pubmed/25115398

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196155/
https://www.ncbi.nlm.nih.gov/pubmed/25115398

Ejemplares similares