Pneumolysin Activates Macrophage Lysosomal Membrane Permeabilization and Executes Apoptosis by Distinct Mechanisms without Membrane Pore Formation

Intracellular killing of Streptococcus pneumoniae is complemented by induction of macrophage apoptosis. Here, we show that the toxin pneumolysin (PLY) contributes both to lysosomal/phagolysosomal membrane permeabilization (LMP), an upstream event programing susceptibility to apoptosis, and to apopto...

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Detalles Bibliográficos
Autores principales: Bewley, Martin A., Naughton, Michael, Preston, Julie, Mitchell, Andrea, Holmes, Ashleigh, Marriott, Helen M., Read, Robert C., Mitchell, Timothy J., Whyte, Moira K. B., Dockrell, David H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Microbiology 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196231/
https://www.ncbi.nlm.nih.gov/pubmed/25293758
http://dx.doi.org/10.1128/mBio.01710-14

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196231/
https://www.ncbi.nlm.nih.gov/pubmed/25293758
http://dx.doi.org/10.1128/mBio.01710-14

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