Failure of cell cleavage induces senescence in tetraploid primary cells

Tetraploidy can arise from various mitotic or cleavage defects in mammalian cells, and inheritance of multiple centrosomes induces aneuploidy when tetraploid cells continue to cycle. Arrest of the tetraploid cell cycle is therefore potentially a critical cellular control. We report here that primary...

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Detalles Bibliográficos
Autores principales: Panopoulos, Andreas, Pacios-Bras, Cristina, Choi, Justin, Yenjerla, Mythili, Sussman, Mark A., Fotedar, Rati, Margolis, Robert L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196863/
https://www.ncbi.nlm.nih.gov/pubmed/25143403
http://dx.doi.org/10.1091/mbc.E14-03-0844

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196863/
https://www.ncbi.nlm.nih.gov/pubmed/25143403
http://dx.doi.org/10.1091/mbc.E14-03-0844

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