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Two Dictyostelium tyrosine kinase–like kinases function in parallel, stress-induced STAT activation pathways

When Dictyostelium cells are hyperosmotically stressed, STATc is activated by tyrosine phosphorylation. Unusually, activation is regulated by serine phosphorylation and consequent inhibition of a tyrosine phosphatase: PTP3. The identity of the cognate tyrosine kinase is unknown, and we show that two...

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Detalles Bibliográficos
Autores principales: Araki, Tsuyoshi, Vu, Linh Hai, Sasaki, Norimitsu, Kawata, Takefumi, Eichinger, Ludwig, Williams, Jeffrey G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196871/
https://www.ncbi.nlm.nih.gov/pubmed/25143406
http://dx.doi.org/10.1091/mbc.E14-07-1182