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A Dynamic View of Molecular Switch Behavior at Serotonin Receptors: Implications for Functional Selectivity
Functional selectivity is a property of G protein-coupled receptors that allows them to preferentially couple to particular signaling partners upon binding of biased agonists. Publication of the X-ray crystal structure of serotonergic 5-HT(1B) and 5-HT(2B) receptors in complex with ergotamine, a dru...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196896/ https://www.ncbi.nlm.nih.gov/pubmed/25313636 http://dx.doi.org/10.1371/journal.pone.0109312 |