Covariance of Charged Amino Acids at Positions 322 and 440 of HIV-1 Env Contributes to Coreceptor Specificity of Subtype B Viruses, and Can Be Used to Improve the Performance of V3 Sequence-Based Coreceptor Usage Prediction Algorithms

The ability to determine coreceptor usage of patient-derived human immunodeficiency virus type 1 (HIV-1) strains is clinically important, particularly for the administration of the CCR5 antagonist maraviroc. The envelope glycoprotein (Env) determinants of coreceptor specificity lie primarily within...

Descripción completa

Detalles Bibliográficos
Autores principales: Cashin, Kieran, Sterjovski, Jasminka, Harvey, Katherine L., Ramsland, Paul A., Churchill, Melissa J., Gorry, Paul R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196930/
https://www.ncbi.nlm.nih.gov/pubmed/25313689
http://dx.doi.org/10.1371/journal.pone.0109771

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196930/
https://www.ncbi.nlm.nih.gov/pubmed/25313689
http://dx.doi.org/10.1371/journal.pone.0109771

Ejemplares similares