Interleukin-1β Induces Blood–Brain Barrier Disruption by Downregulating Sonic Hedgehog in Astrocytes

The blood–brain barrier (BBB) is composed of capillary endothelial cells, pericytes, and perivascular astrocytes, which regulate central nervous system homeostasis. Sonic hedgehog (SHH) released from astrocytes plays an important role in the maintenance of BBB integrity. BBB disruption and microglia...

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Detalles Bibliográficos
Autores principales: Wang, Yue, Jin, Shijie, Sonobe, Yoshifumi, Cheng, Yi, Horiuchi, Hiroshi, Parajuli, Bijay, Kawanokuchi, Jun, Mizuno, Tetsuya, Takeuchi, Hideyuki, Suzumura, Akio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196962/
https://www.ncbi.nlm.nih.gov/pubmed/25313834
http://dx.doi.org/10.1371/journal.pone.0110024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196962/
https://www.ncbi.nlm.nih.gov/pubmed/25313834
http://dx.doi.org/10.1371/journal.pone.0110024

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