Cargando…

Interleukin-1β Induces Blood–Brain Barrier Disruption by Downregulating Sonic Hedgehog in Astrocytes

The blood–brain barrier (BBB) is composed of capillary endothelial cells, pericytes, and perivascular astrocytes, which regulate central nervous system homeostasis. Sonic hedgehog (SHH) released from astrocytes plays an important role in the maintenance of BBB integrity. BBB disruption and microglia...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Yue, Jin, Shijie, Sonobe, Yoshifumi, Cheng, Yi, Horiuchi, Hiroshi, Parajuli, Bijay, Kawanokuchi, Jun, Mizuno, Tetsuya, Takeuchi, Hideyuki, Suzumura, Akio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196962/ https://www.ncbi.nlm.nih.gov/pubmed/25313834 http://dx.doi.org/10.1371/journal.pone.0110024

Ejemplares similares

Fingolimod Phosphate Attenuates Oligomeric Amyloid β–Induced Neurotoxicity via Increased Brain-Derived Neurotrophic Factor Expression in Neurons
por: Doi, Yukiko, et al.
Publicado: (2013)

Interleukin-34 Restores Blood–Brain Barrier Integrity by Upregulating Tight Junction Proteins in Endothelial Cells
por: Jin, Shijie, et al.
Publicado: (2014)

Granulocyte-Colony Stimulating Factor Attenuates Oligomeric Amyloid β Neurotoxicity by Activation of Neprilysin
por: Doi, Yukiko, et al.
Publicado: (2014)

GM-CSF increases LPS-induced production of proinflammatory mediators via upregulation of TLR4 and CD14 in murine microglia
por: Parajuli, Bijay, et al.
Publicado: (2012)

FGF-2 released from degenerating neurons exerts microglial-induced neuroprotection via FGFR3-ERK signaling pathway
por: Noda, Mariko, et al.
Publicado: (2014)

The neuroprotective effects of milk fat globule-EGF factor 8 against oligomeric amyloid β toxicity
por: Li, Endong, et al.
Publicado: (2012)

Interleukin-19 Acts as a Negative Autocrine Regulator of Activated Microglia
por: Horiuchi, Hiroshi, et al.
Publicado: (2015)

Th1 cells downregulate connexin 43 gap junctions in astrocytes via microglial activation
por: Watanabe, Mitsuru, et al.
Publicado: (2016)

Blockade of Gap Junction Hemichannel Suppresses Disease Progression in Mouse Models of Amyotrophic Lateral Sclerosis and Alzheimer's Disease
por: Takeuchi, Hideyuki, et al.
Publicado: (2011)

Interleukin-19 Abrogates Experimental Autoimmune Encephalomyelitis by Attenuating Antigen-Presenting Cell Activation
por: Horiuchi, Hiroshi, et al.
Publicado: (2021)

Sonic hedgehog signaling in astrocytes
por: Hill, Steven A., et al.
Publicado: (2020)

Oligomeric amyloid β induces IL-1β processing via production of ROS: implication in Alzheimer's disease
por: Parajuli, B, et al.
Publicado: (2013)

Resveratrol Downregulates Interleukin-6-Stimulated Sonic Hedgehog Signaling in Human Acute Myeloid Leukemia
por: Su, Yu-Chieh, et al.
Publicado: (2013)

HMGB1 Promotes the Release of Sonic Hedgehog From Astrocytes
por: Xiao, Yifan, et al.
Publicado: (2021)

A subpopulation of astrocyte progenitors defined by Sonic hedgehog signaling
por: Gingrich, Ellen C., et al.
Publicado: (2022)

Sonic hedgehog signalling mediates astrocyte crosstalk with neurons to confer neuroprotection
por: Ugbode, Christopher I., et al.
Publicado: (2017)

Sonic hedgehog signaling in astrocytes mediates cell type-specific synaptic organization
por: Hill, Steven A, et al.
Publicado: (2019)

Sonic Hedgehog receptor Patched deficiency in astrocytes enhances glucose metabolism in mice
por: Tirou, Linda, et al.
Publicado: (2021)

New Tricks for an Old (Hedge)Hog: Sonic Hedgehog Regulation of Astrocyte Function
por: Garcia, A. Denise R.
Publicado: (2021)

Sonic Hedgehog in SCLC
por: Laukkanen, Mikko O., et al.
Publicado: (2015)

Downregulation of Sonic hedgehog signaling induces G2‐arrest in genital warts
por: Du, Xiangxi, et al.
Publicado: (2022)

Sonic hedgehog signaling is negatively regulated in reactive astrocytes after forebrain stab injury
por: Allahyari, R. Vivian, et al.
Publicado: (2019)

Estradiol Triggers Sonic-hedgehog–induced Angiogenesis During Peripheral Nerve Regeneration by Downregulating Hedgehog-interacting Protein
por: Sekiguchi, Haruki, et al.
Publicado: (2012)

Inhibitors of Hedgehog Acyltransferase Block Sonic Hedgehog Signaling
por: Petrova, Elissaveta, et al.
Publicado: (2013)

Regulation of Thalamic Development by Sonic Hedgehog
por: Epstein, Douglas J.
Publicado: (2012)

Probing extracellular Sonic hedgehog in neurons
por: Eitan, Erez, et al.
Publicado: (2016)

Sonic Hedgehog Signaling in Thyroid Cancer
por: Xu, Xiulong, et al.
Publicado: (2017)

A highlight on Sonic hedgehog pathway
por: Carballo, Gabriela Basile, et al.
Publicado: (2018)

Sonic Hedgehog Signaling and Development of the Dentition
por: Seppala, Maisa, et al.
Publicado: (2017)

Sonic Hedgehog Signaling in Limb Development
por: Tickle, Cheryll, et al.
Publicado: (2017)

Sonic hedgehog expression in the postnatal brain
por: Rivell, Aileen, et al.
Publicado: (2019)

Sonic Hedgehog Signaling and Tooth Development
por: Hosoya, Akihiro, et al.
Publicado: (2020)

Downregulation of Wnt signaling by sonic hedgehog activation promotes repopulation of human tumor cell lines
por: Ma, Jingjing, et al.
Publicado: (2015)

Sonic hedgehog functions upstream of disrupted-in-schizophrenia 1 (disc1): implications for mental illness
por: Boyd, Penelope J., et al.
Publicado: (2015)

Sonic hedgehog is a potent chemoattractant for human monocytes: diabetes mellitus inhibits Sonic hedgehog-induced monocyte chemotaxis
por: Dunaeva, Marina, et al.
Publicado: (2009)

Astrocytic Sonic Hedgehog Alleviates Intracerebral Hemorrhagic Brain Injury via Modulation of Blood-Brain Barrier Integrity
por: Xing, Gebeili, et al.
Publicado: (2020)

Human immunodeficiency virus-1 Tat exerts its neurotoxic effects by downregulating Sonic hedgehog signaling
por: khan, Irfan A., et al.
Publicado: (2022)

Developmental pathways: Sonic hedgehog-Patched-GLI.
por: Walterhouse, D O, et al.
Publicado: (1999)

Ontogenetic Expression of Sonic Hedgehog in the Chicken Subpallium
por: Bardet, Sylvia M., et al.
Publicado: (2010)

Sonic hedgehog promotes autophagy in hippocampal neurons
por: Petralia, Ronald S., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_0t6pvd0cm2qu8r94u4mupdfrbe