IFITM3 Polymorphism rs12252-C Restricts Influenza A Viruses

The IFITM3 polymorphism rs12252-C, which encodes an IFITM3 isoform (Δ21 IFITM3) lacking 21 amino acids at the amino terminus, has been controversially associated with poor clinical outcomes in patients with H1N1 influenza A virus (IAV) infections. In vitro studies have shown that Δ21 IFITM3 loses it...

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Detalles Bibliográficos
Autores principales: Williams, David Evan Joseph, Wu, Wan-Lin, Grotefend, Christopher Robert, Radic, Vladimir, Chung, Changik, Chung, Young-Hwa, Farzan, Michael, Huang, I-Chueh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196997/
https://www.ncbi.nlm.nih.gov/pubmed/25314048
http://dx.doi.org/10.1371/journal.pone.0110096

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196997/
https://www.ncbi.nlm.nih.gov/pubmed/25314048
http://dx.doi.org/10.1371/journal.pone.0110096

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