Cardiac ryanodine receptor activation by a high Ca(2+) store load is reversed in a reducing cytoplasmic redox environment

Here, we report the impact of redox potential on isolated cardiac ryanodine receptor (RyR2) channel activity and its response to physiological changes in luminal [Ca(2+)]. Basal leak from the sarcoplasmic reticulum is required for normal Ca(2+) handling, but excess diastolic Ca(2+) leak attributed t...

Descripción completa

Detalles Bibliográficos
Autores principales: Hanna, Amy D., Lam, Alex, Thekkedam, Chris, Gallant, Esther M., Beard, Nicole A., Dulhunty, Angela F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197090/
https://www.ncbi.nlm.nih.gov/pubmed/25146393
http://dx.doi.org/10.1242/jcs.156760

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197090/
https://www.ncbi.nlm.nih.gov/pubmed/25146393
http://dx.doi.org/10.1242/jcs.156760

Ejemplares similares