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Cardiac ryanodine receptor activation by a high Ca(2+) store load is reversed in a reducing cytoplasmic redox environment

Here, we report the impact of redox potential on isolated cardiac ryanodine receptor (RyR2) channel activity and its response to physiological changes in luminal [Ca(2+)]. Basal leak from the sarcoplasmic reticulum is required for normal Ca(2+) handling, but excess diastolic Ca(2+) leak attributed t...

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Detalles Bibliográficos
Autores principales:	Hanna, Amy D., Lam, Alex, Thekkedam, Chris, Gallant, Esther M., Beard, Nicole A., Dulhunty, Angela F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197090/ https://www.ncbi.nlm.nih.gov/pubmed/25146393 http://dx.doi.org/10.1242/jcs.156760

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