Epistatic interactions between neuraminidase mutations facilitated the emergence of the oseltamivir-resistant H1N1 influenza viruses

Oseltamivir-resistant H1N1 influenza viruses carrying the H275Y neuraminidase mutation predominated worldwide during the 2007–2009 seasons. While several neuraminidase substitutions were found to be necessary to counteract the adverse effects of H275Y, the order and impact of evolutionary events inv...

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Detalles Bibliográficos
Autores principales: Duan, Susu, Govorkova, Elena A., Bahl, Justin, Zaraket, Hassan, Baranovich, Tatiana, Seiler, Patrick, Prevost, Kristi, Webster, Robert G., Webby, Richard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197134/
https://www.ncbi.nlm.nih.gov/pubmed/25297528
http://dx.doi.org/10.1038/ncomms6029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197134/
https://www.ncbi.nlm.nih.gov/pubmed/25297528
http://dx.doi.org/10.1038/ncomms6029

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