Statistical measures of transcriptional diversity capture genomic heterogeneity of cancer

BACKGROUND: Molecular heterogeneity of tumors suggests the presence of multiple different subclones that may limit response to targeted therapies and contribute to acquisition of drug resistance, but its quantification has remained challenging. RESULTS: We performed simulations to evaluate statistic...

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Detalles Bibliográficos
Autores principales: Jiang, Tingting, Shi, Weiwei, Natowicz, René, Ononye, Sophia N, Wali, Vikram B, Kluger, Yuval, Pusztai, Lajos, Hatzis, Christos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197225/
https://www.ncbi.nlm.nih.gov/pubmed/25294321
http://dx.doi.org/10.1186/1471-2164-15-876

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197225/
https://www.ncbi.nlm.nih.gov/pubmed/25294321
http://dx.doi.org/10.1186/1471-2164-15-876

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