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CBFB-MYH11 hypomethylation signature and PBX3 differential methylation revealed by targeted bisulfite sequencing in patients with acute myeloid leukemia

BACKGROUND: Studying DNA methylation changes in the context of structural rearrangements and point mutations as well as gene expression changes enables the identification of genes that are important for disease onset and progression in different subtypes of acute myeloid leukemia (AML) patients. The...

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Detalles Bibliográficos
Autores principales: Hájková, Hana, Fritz, Markus Hsi-Yang, Haškovec, Cedrik, Schwarz, Jiří, Šálek, Cyril, Marková, Jana, Krejčík, Zdeněk, Dostálová Merkerová, Michaela, Kostečka, Arnošt, Vostrý, Martin, Fuchs, Ota, Michalová, Kyra, Cetkovský, Petr, Beneš, Vladimír
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197269/
https://www.ncbi.nlm.nih.gov/pubmed/25266220
http://dx.doi.org/10.1186/s13045-014-0066-4