Cargando…

Phosphoinositide 3-kinase p85beta regulates invadopodium formation

The acquisition of invasiveness is characteristic of tumor progression. Numerous genetic changes are associated with metastasis, but the mechanism by which a cell becomes invasive remains unclear. Expression of p85β, a regulatory subunit of phosphoinositide-3-kinase, markedly increases in advanced c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cariaga-Martínez, Ariel E., Cortés, Isabel, García, Esther, Pérez-García, Vicente, Pajares, María J., Idoate, Miguel A., Redondo-Muñóz, Javier, Antón, Inés M., Carrera, Ana C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197441/ https://www.ncbi.nlm.nih.gov/pubmed/25217619 http://dx.doi.org/10.1242/bio.20148185

Ejemplares similares

Phosphoinositide 3-kinase beta controls replication factor C assembly and function
por: Redondo-Muñoz, Javier, et al.
Publicado: (2013)

p85β increases phosphoinositide 3-kinase activity and accelerates tumor progression
por: González-García, Ana, et al.
Publicado: (2012)

WIP and WICH/WIRE co-ordinately control invadopodium formation and maturation in human breast cancer cell invasion
por: García, Esther, et al.
Publicado: (2016)

Phosphoinositide 3-kinase β regulates chromosome segregation in mitosis
por: Silió, Virginia, et al.
Publicado: (2012)

VCA nanobodies target N-WASp to reduce invadopodium formation and functioning
por: Hebbrecht, Tim, et al.
Publicado: (2017)

Mena(INV) dysregulates cortactin phosphorylation to promote invadopodium maturation
por: Weidmann, Maxwell D., et al.
Publicado: (2016)

Molecular mechanisms of invadopodium formation: the role of the N-WASP–Arp2/3 complex pathway and cofilin
por: Yamaguchi, Hideki, et al.
Publicado: (2005)

STIM1- and Orai1-mediated Ca(2+) oscillation orchestrates invadopodium formation and melanoma invasion
por: Sun, Jianwei, et al.
Publicado: (2014)

The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex
por: Luo, Ji, et al.
Publicado: (2005)

Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation
por: Oser, Matthew, et al.
Publicado: (2009)

Targeting SNARE-Mediated Vesicle Transport to Block Invadopodium-Based Cancer Cell Invasion
por: Gorshtein, Genya, et al.
Publicado: (2021)

Macrophage-dependent tumor cell transendothelial migration is mediated by Notch1/Mena(INV)-initiated invadopodium formation
por: Pignatelli, Jeanine, et al.
Publicado: (2016)

PLXDC2 enhances invadopodium formation to promote invasion and metastasis of gastric cancer cells via interacting with PTP1B
por: Wu, Bin, et al.
Publicado: (2022)

C-SH2 point mutation converts p85β regulatory subunit of phosphoinositide 3-kinase to an anti-aging gene
por: Kano, Yoshio, et al.
Publicado: (2019)

Inhibitors of phosphoinositide 3-kinase (PI3K) and phosphoinositide 3-kinase-related protein kinase family (PIKK)
por: Huang, Xueqin, et al.
Publicado: (2023)

Integrin-dependent translocation of phosphoinositide 3-kinase to the cytoskeleton of thrombin-activated platelets involves specific interactions of p85 alpha with actin filaments and focal adhesion kinase
Publicado: (1995)

Autophosphorylation of serine 608 in the p85 regulatory subunit of wild type or cancer-associated mutants of phosphoinositide 3-kinase does not affect its lipid kinase activity
por: Layton, Meredith J, et al.
Publicado: (2012)

Phosphoinositide 3-kinase class II beta is a novel target in breast cancer therapy
por: Abbott, J, et al.
Publicado: (2010)

Phosphoinositide 3–kinase γ participates in T cell receptor–induced T cell activation
por: Alcázar, Isabela, et al.
Publicado: (2007)

Phosphoinositide Signaling and Mechanotransduction in Cardiovascular Biology and Disease
por: Krajnik, Amanda, et al.
Publicado: (2020)

Advances in Understanding TKS4 and TKS5: Molecular Scaffolds Regulating Cellular Processes from Podosome and Invadopodium Formation to Differentiation and Tissue Homeostasis
por: Kudlik, Gyöngyi, et al.
Publicado: (2020)

Phosphoinositide-3-Kinase Is the Primary Mediator of Phosphoinositide-Dependent Inhibition in Mammalian Olfactory Receptor Neurons
por: Ukhanov, Kirill, et al.
Publicado: (2016)

Dynamics of the Phosphoinositide 3-Kinase p110δ Interaction with p85α and Membranes Reveals Aspects of Regulation Distinct from p110α
por: Burke, John E., et al.
Publicado: (2011)

Exogenous Therapeutics of Microrna-29a Attenuates Development of Hepatic Fibrosis in Cholestatic Animal Model through Regulation of Phosphoinositide 3-Kinase p85 Alpha
por: Yang, Ya-Ling, et al.
Publicado: (2020)

Non-catalytic role of phosphoinositide 3-kinase in mesenchymal cell migration through non-canonical induction of p85β/AP-2-mediated endocytosis
por: Matsubayashi, Hideaki T., et al.
Publicado: (2023)

Non-catalytic role of phosphoinositide 3-kinase in mesenchymal cell migration through non-canonical induction of p85β/AP-2-mediated endocytosis
por: Matsubayashi, Hideaki, et al.
Publicado: (2023)

Phosphoinositide 3-Kinase Inhibitor-Induced Hyperglycemia
por: Shey, Susan, et al.
Publicado: (2021)

Identification of Potential Chemical Substrates as Fuel for Hypoxic Tumors That May Be Linked to Invadopodium Formation in Hypoxia-Induced MDA-MB-231 Breast-Cancer Cell Line
por: Hamad, Hamad Ali, et al.
Publicado: (2020)

Targeted depletion of PIK3R2 induces regression of lung squamous cell carcinoma
por: Vallejo-Díaz, Jesús, et al.
Publicado: (2016)

The Role of Phosphoinositide 3-Kinase Signaling in Intestinal Inflammation
por: Cahill, Catherine M., et al.
Publicado: (2012)

The role of phosphoinositide 3-kinase subunits in chronic thyroiditis
por: Wojciechowska-Durczynska, Katarzyna, et al.
Publicado: (2012)

Phosphoinositide 3-kinase: friend and foe in cardiovascular disease
por: Ghigo, Alessandra, et al.
Publicado: (2015)

The phosphoinositide 3-kinase pathway and therapy resistance in cancer
por: Brown, Kristin K., et al.
Publicado: (2015)

Phosphoinositides, kinases and adaptors coordinating endocytosis in Trypanosoma brucei
por: Manna, Paul T, et al.
Publicado: (2016)

Multiple Functions of Phosphoinositide-3 Kinase Enhancer (PIKE)
por: Chan, Chi Bun, et al.
Publicado: (2010)

Class (I) Phosphoinositide 3-Kinases in the Tumor Microenvironment
por: Gyori, David, et al.
Publicado: (2017)

Psoriasiform eruptions secondary to phosphoinositide 3-kinase inhibition
por: Dewan, Anna K., et al.
Publicado: (2019)

Phosphoinositide 3′-Kinase γ Facilitates Polyomavirus Infection
por: Clark, Paul, et al.
Publicado: (2020)

Phosphoinositide 3-Kinases as Potential Targets for Thrombosis Prevention
por: Setiabakti, Natasha M., et al.
Publicado: (2022)

Disease Evolution and Response to Rapamycin in Activated Phosphoinositide 3-Kinase δ Syndrome: The European Society for Immunodeficiencies-Activated Phosphoinositide 3-Kinase δ Syndrome Registry
por: Maccari, Maria Elena, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_b45hjo72vfsm9qmcbtrf6vgbfh