Differential loss of thalamostriatal and corticostriatal input to striatal projection neuron types prior to overt motor symptoms in the Q140 knock-in mouse model of Huntington's disease

Motor slowing and forebrain white matter loss have been reported in premanifest Huntington's disease (HD) prior to substantial striatal neuron loss. These findings raise the possibility that early motor defects in HD may be related to loss of excitatory input to striatum. In a prior study, we s...

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Detalles Bibliográficos
Autores principales: Deng, Yun-Ping, Wong, Ting, Wan, Jim Y., Reiner, Anton
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197654/
https://www.ncbi.nlm.nih.gov/pubmed/25360089
http://dx.doi.org/10.3389/fnsys.2014.00198

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197654/
https://www.ncbi.nlm.nih.gov/pubmed/25360089
http://dx.doi.org/10.3389/fnsys.2014.00198

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