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Pin1-dependent signalling negatively affects GABAergic transmission by modulating neuroligin2/gephyrin interaction

The cell adhesion molecule Neuroligin2 (NL2) is localized selectively at GABAergic synapses, where it interacts with the scaffolding protein gephyrin in the post-synaptic density. However, the role of this interaction for formation and plasticity of GABAergic synapses is unclear. Here, we demonstrat...

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Detalles Bibliográficos
Autores principales: Antonelli, Roberta, Pizzarelli, Rocco, Pedroni, Andrea, Fritschy, Jean-Marc, Del Sal, Giannino, Cherubini, Enrico, Zacchi, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197815/
https://www.ncbi.nlm.nih.gov/pubmed/25297980
http://dx.doi.org/10.1038/ncomms6066