Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB

Accumulating evidence implicates impairment of the autophagy-lysosome pathway in Alzheimer's disease (AD). Recently discovered, transcription factor EB (TFEB) is a molecule shown to play central roles in cellular degradative processes. Here we investigate the role of TFEB in AD mouse models. In...

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Detalles Bibliográficos
Autores principales: Polito, Vinicia A, Li, Hongmei, Martini-Stoica, Heidi, Wang, Baiping, Yang, Li, Xu, Yin, Swartzlander, Daniel B, Palmieri, Michela, di Ronza, Alberto, Lee, Virginia M-Y, Sardiello, Marco, Ballabio, Andrea, Zheng, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197862/
https://www.ncbi.nlm.nih.gov/pubmed/25069841
http://dx.doi.org/10.15252/emmm.201303671

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197862/
https://www.ncbi.nlm.nih.gov/pubmed/25069841
http://dx.doi.org/10.15252/emmm.201303671

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