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ZBTB7A acts as a tumor suppressor through the transcriptional repression of glycolysis
Elevated glycolysis is a common metabolic trait of cancer, but what drives such metabolic reprogramming remains incompletely clear. We report here a novel transcriptional repressor-mediated negative regulation of glycolysis. ZBTB7A, a member of the POK (POZ/BTB and Krüppel) transcription repressor f...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197949/ https://www.ncbi.nlm.nih.gov/pubmed/25184678 http://dx.doi.org/10.1101/gad.245910.114 |
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author | Liu, Xue-Song Haines, Jenna E. Mehanna, Elie K. Genet, Matthew D. Ben-Sahra, Issam Asara, John M. Manning, Brendan D. Yuan, Zhi-Min |
author_facet | Liu, Xue-Song Haines, Jenna E. Mehanna, Elie K. Genet, Matthew D. Ben-Sahra, Issam Asara, John M. Manning, Brendan D. Yuan, Zhi-Min |
author_sort | Liu, Xue-Song |
collection | PubMed |
description | Elevated glycolysis is a common metabolic trait of cancer, but what drives such metabolic reprogramming remains incompletely clear. We report here a novel transcriptional repressor-mediated negative regulation of glycolysis. ZBTB7A, a member of the POK (POZ/BTB and Krüppel) transcription repressor family, directly binds to the promoter and represses the transcription of critical glycolytic genes, including GLUT3, PFKP, and PKM. Analysis of The Cancer Genome Atlas (TCGA) data sets reveals that the ZBTB7A locus is frequently deleted in many human tumors. Significantly, reduced ZBTB7A expression correlates with up-regulation of the glycolytic genes and poor survival in colon cancer patients. Remarkably, while ZBTB7A-deficient tumors progress exceedingly fast, they exhibit an unusually heightened sensitivity to glycolysis inhibition. Our study uncovers a novel tumor suppressor role of ZBTB7A in directly suppressing glycolysis. |
format | Online Article Text |
id | pubmed-4197949 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Cold Spring Harbor Laboratory Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-41979492015-03-01 ZBTB7A acts as a tumor suppressor through the transcriptional repression of glycolysis Liu, Xue-Song Haines, Jenna E. Mehanna, Elie K. Genet, Matthew D. Ben-Sahra, Issam Asara, John M. Manning, Brendan D. Yuan, Zhi-Min Genes Dev Research Paper Elevated glycolysis is a common metabolic trait of cancer, but what drives such metabolic reprogramming remains incompletely clear. We report here a novel transcriptional repressor-mediated negative regulation of glycolysis. ZBTB7A, a member of the POK (POZ/BTB and Krüppel) transcription repressor family, directly binds to the promoter and represses the transcription of critical glycolytic genes, including GLUT3, PFKP, and PKM. Analysis of The Cancer Genome Atlas (TCGA) data sets reveals that the ZBTB7A locus is frequently deleted in many human tumors. Significantly, reduced ZBTB7A expression correlates with up-regulation of the glycolytic genes and poor survival in colon cancer patients. Remarkably, while ZBTB7A-deficient tumors progress exceedingly fast, they exhibit an unusually heightened sensitivity to glycolysis inhibition. Our study uncovers a novel tumor suppressor role of ZBTB7A in directly suppressing glycolysis. Cold Spring Harbor Laboratory Press 2014-09-01 /pmc/articles/PMC4197949/ /pubmed/25184678 http://dx.doi.org/10.1101/gad.245910.114 Text en © 2014 Liu et al.; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Research Paper Liu, Xue-Song Haines, Jenna E. Mehanna, Elie K. Genet, Matthew D. Ben-Sahra, Issam Asara, John M. Manning, Brendan D. Yuan, Zhi-Min ZBTB7A acts as a tumor suppressor through the transcriptional repression of glycolysis |
title | ZBTB7A acts as a tumor suppressor through the transcriptional repression of glycolysis |
title_full | ZBTB7A acts as a tumor suppressor through the transcriptional repression of glycolysis |
title_fullStr | ZBTB7A acts as a tumor suppressor through the transcriptional repression of glycolysis |
title_full_unstemmed | ZBTB7A acts as a tumor suppressor through the transcriptional repression of glycolysis |
title_short | ZBTB7A acts as a tumor suppressor through the transcriptional repression of glycolysis |
title_sort | zbtb7a acts as a tumor suppressor through the transcriptional repression of glycolysis |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197949/ https://www.ncbi.nlm.nih.gov/pubmed/25184678 http://dx.doi.org/10.1101/gad.245910.114 |
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