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Modern genome editing meets telomeres: the many functions of TPP1
The telomeric complex has been analyzed in detail for its role in regulating telomere protection and telomere length. Now, modern genome-editing techniques in human embryonic stem cells reveal TPP1 as the essential recruitment factor for telomerase, with additional functions in telomerase activation...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cold Spring Harbor Laboratory Press
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197952/ https://www.ncbi.nlm.nih.gov/pubmed/25184673 http://dx.doi.org/10.1101/gad.250316.114 |