Modern genome editing meets telomeres: the many functions of TPP1

The telomeric complex has been analyzed in detail for its role in regulating telomere protection and telomere length. Now, modern genome-editing techniques in human embryonic stem cells reveal TPP1 as the essential recruitment factor for telomerase, with additional functions in telomerase activation...

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Detalles Bibliográficos
Autor principal: Karlseder, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197952/
https://www.ncbi.nlm.nih.gov/pubmed/25184673
http://dx.doi.org/10.1101/gad.250316.114
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author Karlseder, Jan
author_facet Karlseder, Jan
author_sort Karlseder, Jan
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description The telomeric complex has been analyzed in detail for its role in regulating telomere protection and telomere length. Now, modern genome-editing techniques in human embryonic stem cells reveal TPP1 as the essential recruitment factor for telomerase, with additional functions in telomerase activation and definition of telomere length homeostasis.
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spelling pubmed-41979522015-03-01 Modern genome editing meets telomeres: the many functions of TPP1 Karlseder, Jan Genes Dev Perspective The telomeric complex has been analyzed in detail for its role in regulating telomere protection and telomere length. Now, modern genome-editing techniques in human embryonic stem cells reveal TPP1 as the essential recruitment factor for telomerase, with additional functions in telomerase activation and definition of telomere length homeostasis. Cold Spring Harbor Laboratory Press 2014-09-01 /pmc/articles/PMC4197952/ /pubmed/25184673 http://dx.doi.org/10.1101/gad.250316.114 Text en © 2014 Karlseder; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Perspective
Karlseder, Jan
Modern genome editing meets telomeres: the many functions of TPP1
title Modern genome editing meets telomeres: the many functions of TPP1
title_full Modern genome editing meets telomeres: the many functions of TPP1
title_fullStr Modern genome editing meets telomeres: the many functions of TPP1
title_full_unstemmed Modern genome editing meets telomeres: the many functions of TPP1
title_short Modern genome editing meets telomeres: the many functions of TPP1
title_sort modern genome editing meets telomeres: the many functions of tpp1
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197952/
https://www.ncbi.nlm.nih.gov/pubmed/25184673
http://dx.doi.org/10.1101/gad.250316.114
work_keys_str_mv AT karlsederjan moderngenomeeditingmeetstelomeresthemanyfunctionsoftpp1

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