PET Imaging Demonstrates Histone Deacetylase Target Engagement and Clarifies Brain Penetrance of Known and Novel Small Molecule Inhibitors in Rat

[Image: see text] Histone deacetylase (HDAC) enzymes have been demonstrated as critical components in maintaining chromatin homeostasis, CNS development, and normal brain function. Evidence in mouse models links HDAC expression to learning, memory, and mood-related behaviors; small molecule HDAC inh...

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Detalles Bibliográficos
Autores principales: Schroeder, F. A., Wang, C., Van de Bittner, G. C., Neelamegam, R., Takakura, W. R., Karunakaran, A., Wey, H. Y., Reis, S. A., Gale, J., Zhang, Y. L., Holson, E. B., Haggarty, S. J., Hooker, J. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198064/
https://www.ncbi.nlm.nih.gov/pubmed/25188794
http://dx.doi.org/10.1021/cn500162j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198064/
https://www.ncbi.nlm.nih.gov/pubmed/25188794
http://dx.doi.org/10.1021/cn500162j

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