TGFβ-Induced Deptor Suppression Recruits mTORC1 and Not mTORC2 to Enhance Collagen I (α2) Gene Expression

Enhanced TGFβ activity contributes to the accumulation of matrix proteins including collagen I (α2) by proximal tubular epithelial cells in progressive kidney disease. Although TGFβ rapidly activates its canonical Smad signaling pathway, it also recruits noncanonical pathway involving mTOR kinase to...

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Detalles Bibliográficos
Autores principales: Das, Falguni, Bera, Amit, Ghosh-Choudhury, Nandini, Abboud, Hanna E., Kasinath, Balakuntalam S., Choudhury, Goutam Ghosh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198127/
https://www.ncbi.nlm.nih.gov/pubmed/25333702
http://dx.doi.org/10.1371/journal.pone.0109608

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198127/
https://www.ncbi.nlm.nih.gov/pubmed/25333702
http://dx.doi.org/10.1371/journal.pone.0109608

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