Targeting of Repeated Sequences Unique to a Gene Results in Significant Increases in Antisense Oligonucleotide Potency

A new strategy for identifying potent RNase H-dependent antisense oligonucleotides (ASOs) is presented. Our analysis of the human transcriptome revealed that a significant proportion of genes contain unique repeated sequences of 16 or more nucleotides in length. Activities of ASOs targeting these re...

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Detalles Bibliográficos
Autores principales: Vickers, Timothy A., Freier, Susan M., Bui, Huynh-Hoa, Watt, Andrew, Crooke, Stanley T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198294/
https://www.ncbi.nlm.nih.gov/pubmed/25334092
http://dx.doi.org/10.1371/journal.pone.0110615

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198294/
https://www.ncbi.nlm.nih.gov/pubmed/25334092
http://dx.doi.org/10.1371/journal.pone.0110615

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