5-aza-2′-deoxycytidine-mediated c-myc Down-regulation Triggers Telomere-dependent Senescence by Regulating Human Telomerase Reverse Transcriptase in Chronic Myeloid Leukemia()

Increased proliferation rates as well as resistance to apoptosis are considered major obstacles for the treatment of patients with chronic myelogenous leukemia (CML), thus highlighting the need for novel therapeutic approaches. Since senescence has been recognized as a physiological barrier against...

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Detalles Bibliográficos
Autores principales: Grandjenette, Cindy, Schnekenburger, Michael, Karius, Tommy, Ghelfi, Jenny, Gaigneaux, Anthoula, Henry, Estelle, Dicato, Mario, Diederich, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198755/
https://www.ncbi.nlm.nih.gov/pubmed/24970385
http://dx.doi.org/10.1016/j.neo.2014.05.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198755/
https://www.ncbi.nlm.nih.gov/pubmed/24970385
http://dx.doi.org/10.1016/j.neo.2014.05.009

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