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T-cell receptor repertoires share a restricted set of public and abundant CDR3 sequences that are associated with self-related immunity
The T-cell receptor (TCR) repertoire is formed by random recombinations of genomic precursor elements; the resulting combinatorial diversity renders unlikely extensive TCR sharing between individuals. Here, we studied CDR3β amino acid sequence sharing in a repertoire-wide manner, using high-throughp...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199372/ https://www.ncbi.nlm.nih.gov/pubmed/25024161 http://dx.doi.org/10.1101/gr.170753.113 |