Hepatotoxicity in Mice of a Novel Anti-parasite Drug Candidate Hydroxymethylnitrofurazone: A Comparison with Benznidazole

BACKGROUND: Treatment of Chagas disease, caused by Trypanosoma cruzi, relies on nifurtimox and benznidazole (BZL), which present side effects in adult patients, and natural resistance in some parasite strains. Hydroxymethylnitrofurazone (NFOH) is a new drug candidate with demonstrated trypanocidal a...

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Detalles Bibliográficos
Autores principales: Davies, Carolina, Dey, Nilay, Negrette, Olga Sanchez, Parada, Luis Antonio, Basombrio, Miguel A., Garg, Nisha Jain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199569/
https://www.ncbi.nlm.nih.gov/pubmed/25329323
http://dx.doi.org/10.1371/journal.pntd.0003231

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199569/
https://www.ncbi.nlm.nih.gov/pubmed/25329323
http://dx.doi.org/10.1371/journal.pntd.0003231

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