A Gain-of-Function Mutation in Adenylate Cyclase 3 Protects Mice from Diet-Induced Obesity

In a screen for genes that affect the metabolic response to high-fat diet (HFD), we selected one line of N-ethyl-N-nitrosourea (ENU)-mutagenized mice, Jll, with dominantly inherited resistance to diet-induced obesity (DIO). Mutant animals had dramatically reduced body weight and fat mass, and low ba...

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Detalles Bibliográficos
Autores principales: Pitman, Jeffrey L., Wheeler, Matthew C., Lloyd, David J., Walker, John R., Glynne, Richard J., Gekakis, Nicholas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199629/
https://www.ncbi.nlm.nih.gov/pubmed/25329148
http://dx.doi.org/10.1371/journal.pone.0110226

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199629/
https://www.ncbi.nlm.nih.gov/pubmed/25329148
http://dx.doi.org/10.1371/journal.pone.0110226

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