Effects of Cytochrome P450 2C19 and Paraoxonase 1 Polymorphisms on Antiplatelet Response to Clopidogrel Therapy in Patients with Coronary Artery Disease

Clopidogrel is an antiplatelet prodrug that is recommended to reduce the risk of recurrent thrombosis in coronary artery disease (CAD) patients. Paraoxonase 1 (PON1) is suggested to be a rate-limiting enzyme in the conversion of 2-oxo-clopidogrel to active thiol metabolite with inconsistent results....

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Detalles Bibliográficos
Autores principales: Tresukosol, Damrus, Suktitipat, Bhoom, Hunnangkul, Saowalak, Kamkaew, Ruttakarn, Poldee, Saiphon, Tassaneetrithep, Boonrat, Likidlilid, Atip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199712/
https://www.ncbi.nlm.nih.gov/pubmed/25329996
http://dx.doi.org/10.1371/journal.pone.0110188

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199712/
https://www.ncbi.nlm.nih.gov/pubmed/25329996
http://dx.doi.org/10.1371/journal.pone.0110188

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