Free Energy of Binding of Coiled-Coil Complexes with Different Electrostatic Environments: The Influence of Force Field Polarisation and Capping

Coiled-coils are well known protein–protein interaction motifs, with the leucine zipper region of activator protein-1 (AP-1) consisting of the c-Jun and c-Fos proteins being a typical example. Molecular dynamics (MD) simulations using the MM/GBSA method have been used to predict the free energy of i...

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Detalles Bibliográficos
Autores principales: Zuo, Zhi-Li, Guo, Ling, Mancera, Ricardo L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199946/
https://www.ncbi.nlm.nih.gov/pubmed/25159896
http://dx.doi.org/10.1007/s13659-014-0036-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199946/
https://www.ncbi.nlm.nih.gov/pubmed/25159896
http://dx.doi.org/10.1007/s13659-014-0036-0

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