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Anti-proliferative but not anti-angiogenic tyrosine kinase inhibitors enrich for cancer stem cells in soft tissue sarcoma
BACKGROUND: Increasing studies implicate cancer stem cells (CSCs) as the source of resistance and relapse following conventional cytotoxic therapies. Few studies have examined the response of CSCs to targeted therapies, such as tyrosine kinase inhibitors (TKIs). We hypothesized that TKIs would have...
Autores principales: | Canter, Robert J, Ames, Erik, Mac, Stephanie, Grossenbacher, Steven K, Chen, Mingyi, Li, Chin-Shang, Borys, Dariusz, Smith, Rachel C, Tellez, Joe, Sayers, Thomas J, Monjazeb, Arta M, Murphy, William J |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200119/ https://www.ncbi.nlm.nih.gov/pubmed/25301268 http://dx.doi.org/10.1186/1471-2407-14-756 |
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