Glutamine deprivation stimulates mTOR-JNK-dependent chemokine secretion

The non-essential amino acid, glutamine, exerts pleiotropic effects on cell metabolism, signalling and stress resistance. Here we demonstrate that short-term glutamine restriction triggers an endoplasmic reticulum (ER) stress response that leads to production of the pro-inflammatory chemokine, inter...

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Detalles Bibliográficos
Autores principales: Shanware, Naval P., Bray, Kevin, Eng, Christina H., Wang, Fang, Follettie, Maximillian, Myers, Jeremy, Fantin, Valeria R., Abraham, Robert T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200525/
https://www.ncbi.nlm.nih.gov/pubmed/25254627
http://dx.doi.org/10.1038/ncomms5900

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200525/
https://www.ncbi.nlm.nih.gov/pubmed/25254627
http://dx.doi.org/10.1038/ncomms5900

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