Design, Synthesis and Biological Evaluation of Sulfamide and Triazole Benzodiazepines as Novel p53-MDM2 Inhibitors

A series of sulfamide and triazole benzodiazepines were obtained with the principle of bioisosterism. The p53-murine double minute 2 (MDM2) inhibitory activity and in vitro antitumor activity were evaluated. Most of the novel benzodiazepines exhibited moderate protein binding inhibitory activity. Pa...

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Detalles Bibliográficos
Autores principales: Yu, Zhiliang, Zhuang, Chunlin, Wu, Yuelin, Guo, Zizhao, Li, Jin, Dong, Guoqiang, Yao, Jianzhong, Sheng, Chunquan, Miao, Zhenyuan, Zhang, Wannian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200789/
https://www.ncbi.nlm.nih.gov/pubmed/25198897
http://dx.doi.org/10.3390/ijms150915741

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200789/
https://www.ncbi.nlm.nih.gov/pubmed/25198897
http://dx.doi.org/10.3390/ijms150915741

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