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Generation and Characterisation of Mice Deficient in the Multi-GTPase Domain Containing Protein, GIMAP8

BACKGROUND: GTPases of the immunity-associated protein family (GIMAPs) are predominantly expressed in mature lymphocytes. Studies of rodents deficient in GIMAP1, GIMAP4, or GIMAP5 have demonstrated that these GTPases regulate lymphocyte survival. In contrast to the other family members, GIMAP8 conta...

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Detalles Bibliográficos
Autores principales: Webb, Louise M. C., Pascall, John C., Hepburn, Lucy, Carter, Christine, Turner, Martin, Butcher, Geoffrey W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201521/
https://www.ncbi.nlm.nih.gov/pubmed/25329815
http://dx.doi.org/10.1371/journal.pone.0110294