Cargando…

Generation and Characterisation of Mice Deficient in the Multi-GTPase Domain Containing Protein, GIMAP8

BACKGROUND: GTPases of the immunity-associated protein family (GIMAPs) are predominantly expressed in mature lymphocytes. Studies of rodents deficient in GIMAP1, GIMAP4, or GIMAP5 have demonstrated that these GTPases regulate lymphocyte survival. In contrast to the other family members, GIMAP8 conta...

Descripción completa

Detalles Bibliográficos
Autores principales:	Webb, Louise M. C., Pascall, John C., Hepburn, Lucy, Carter, Christine, Turner, Martin, Butcher, Geoffrey W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201521/ https://www.ncbi.nlm.nih.gov/pubmed/25329815 http://dx.doi.org/10.1371/journal.pone.0110294

Ejemplares similares

Expression of GIMAP1, a GTPase of the immunity-associated protein family, is not up-regulated in malaria
por: Saunders, Amy, et al.
Publicado: (2009)

The Immune System GTPase GIMAP6 Interacts with the Atg8 Homologue GABARAPL2 and Is Recruited to Autophagosomes
por: Pascall, John C., et al.
Publicado: (2013)

Survival of mature T cells in the periphery is intrinsically dependent on GIMAP1 in mice
por: Datta, Preeta, et al.
Publicado: (2016)

GIMAP6 is required for T cell maintenance and efficient autophagy in mice
por: Pascall, John C., et al.
Publicado: (2018)

GIMAP Proteins in T-Lymphocytes
por: Filén, Sanna, et al.
Publicado: (2010)

GIMAP5 Deficiency Is Associated with Increased AKT Activity in T Lymphocytes
por: Chen, Xi-Lin, et al.
Publicado: (2015)

Patchy Distribution of GTPases of Immunity-Associated Proteins (GIMAP) within Cnidarians and Dinoflagellates Suggests a Complex Evolutionary History
por: Coelho, Jenny C, et al.
Publicado: (2022)

GIMAP6 regulates autophagy, immune competence, and inflammation in mice and humans
por: Yao, Yikun, et al.
Publicado: (2022)

A human case of GIMAP6 deficiency: a novel primary immune deficiency
por: Shadur, Bella, et al.
Publicado: (2020)

The GIMAP Family Proteins: An Incomplete Puzzle
por: Limoges, Marc-André, et al.
Publicado: (2021)

CHOP Mediates Endoplasmic Reticulum Stress-Induced Apoptosis in Gimap5-Deficient T Cells
por: Pino, Steven C., et al.
Publicado: (2009)

TCR and IL-7 Signaling Are Altered in the Absence of Functional GTPase of the Immune Associated Nucleotide Binding Protein 5 (GIMAP5)
por: Chen, Xi-Lin, et al.
Publicado: (2016)

Transcriptomic study in women with trisomy 21 identifies a possible role of the GTPases of the immunity-associated proteins (GIMAP) in the protection of breast cancer
por: Mégarbané, André, et al.
Publicado: (2020)

Gimap3 Regulates Tissue-Specific Mitochondrial DNA Segregation
por: Jokinen, Riikka, et al.
Publicado: (2010)

Characterisation of the Ral GTPase inhibitor RBC8 in human and mouse platelets
por: Walsh, Tony G., et al.
Publicado: (2019)

Sequence Variation and Expression of the Gimap Gene Family in the BB Rat
por: Rutledge, Elizabeth A., et al.
Publicado: (2009)

Exploring the expression and preliminary function of chicken Gimap5 gene
por: Zhang, Wanting, et al.
Publicado: (2019)

GIMAP5 maintains liver endothelial cell homeostasis and prevents portal hypertension
por: Drzewiecki, Kaela, et al.
Publicado: (2021)

Critical role for Gimap5 in the survival of mouse hematopoietic stem and progenitor cells
por: Chen, Yuhong, et al.
Publicado: (2011)

Central Role of Gimap5 in Maintaining Peripheral Tolerance and T Cell Homeostasis in the Gut
por: Endale, Mehari, et al.
Publicado: (2015)

Gimap5 Inhibits Lung Cancer Growth by Interacting With M6PR
por: Dai, Pei, et al.
Publicado: (2021)

p190RhoGAP proteins contain pseudoGTPase domains
por: Stiegler, Amy L., et al.
Publicado: (2017)

Aberrant Activation of the GIMAP Enhancer by Oncogenic Transcription Factors in T-cell Acute Lymphoblastic Leukemia
por: Liau, Wei-Siang, et al.
Publicado: (2016)

Systemic analyses of expression patterns and clinical features for GIMAPs family members in lung adenocarcinoma
por: Deng, Sisi, et al.
Publicado: (2020)

GIMAP7 as a Potential Predictive Marker for Pan-Cancer Prognosis and Immunotherapy Efficacy
por: Qin, Yan, et al.
Publicado: (2022)

TbFRP, a novel FYVE-domain containing phosphoinositide-binding Ras-like GTPase from trypanosomes
por: Adung’a, Vincent O., et al.
Publicado: (2013)

Tubulin- and actin-associating GIMAP4 is required for IFN-γ secretion during Th cell differentiation
por: Heinonen, Mirkka T, et al.
Publicado: (2015)

Associations among PH and SH3 domain-containing proteins and Rho-type GTPases in Yeast
Publicado: (1996)

Prognostic Value of GIMAP4 and Its Role in Promoting Immune Cell Infiltration into Tumor Microenvironment of Lung Adenocarcinoma
por: Chen, Siyuan, et al.
Publicado: (2022)

Radiogenomic Features of GIMAP Family Genes in Clear Cell Renal Cell Carcinoma: An Observational Study on CT Images
por: Greco, Federico, et al.
Publicado: (2023)

Characterisation of a putative M23-domain containing protein in Mycobacterium tuberculosis
por: Papadopoulos, Andrea Olga, et al.
Publicado: (2021)

Intrapolypeptide Interactions between the GTPase Effector Domain (GED) and the GTPase Domain Form the Bundle Signaling Element in Dynamin Dimers
por: Srinivasan, Saipraveen, et al.
Publicado: (2014)

Gimap5-dependent inactivation of GSK3β is required for CD4(+) T cell homeostasis and prevention of immune pathology
por: Patterson, Andrew R., et al.
Publicado: (2018)

Aberrant GIMAP2 expression affects oral squamous cell carcinoma progression by promoting cell cycle and inhibiting apoptosis
por: Komatsu, Mari, et al.
Publicado: (2022)

Control of Rho GTPase function by BAR-domains
por: de Kreuk, Bart-Jan, et al.
Publicado: (2012)

Integrated Bioinformatical Analysis Identifies GIMAP4 as an Immune-Related Prognostic Biomarker Associated With Remodeling in Cervical Cancer Tumor Microenvironment
por: Xu, Fangfang, et al.
Publicado: (2021)

Characterisations of human prostate stem cells reveal deficiency in class I UGT enzymes as a novel mechanism for castration-resistant prostate cancer
por: Williamson, S C, et al.
Publicado: (2013)

SET Domain Containing 2 Deficiency in Myelodysplastic Syndrome
por: Li, Jiaming, et al.
Publicado: (2020)

Rac GTPases: domain-specific functions in neuronal development
por: Nørgaard, Steffen, et al.
Publicado: (2019)

Mevalonate kinase deficiency leads to decreased prenylation of Rab GTPases
por: Jurczyluk, Julie, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_agrr6lscmkgc9vk2jr9beok74f