Loss of Cln3 Function in the Social Amoeba Dictyostelium discoideum Causes Pleiotropic Effects That Are Rescued by Human CLN3

The neuronal ceroid lipofuscinoses (NCL) are a group of inherited, severe neurodegenerative disorders also known as Batten disease. Juvenile NCL (JNCL) is caused by recessive loss-of-function mutations in CLN3, which encodes a transmembrane protein that regulates endocytic pathway trafficking, thoug...

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Detalles Bibliográficos
Autores principales: Huber, Robert J., Myre, Michael A., Cotman, Susan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201555/
https://www.ncbi.nlm.nih.gov/pubmed/25330233
http://dx.doi.org/10.1371/journal.pone.0110544

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201555/
https://www.ncbi.nlm.nih.gov/pubmed/25330233
http://dx.doi.org/10.1371/journal.pone.0110544

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