Diapocynin, a Dimer of the NADPH Oxidase Inhibitor Apocynin, Reduces ROS Production and Prevents Force Loss in Eccentrically Contracting Dystrophic Muscle

Elevation of intracellular Ca(2+), excessive ROS production and increased phospholipase A(2) activity contribute to the pathology in dystrophin-deficient muscle. Moreover, Ca(2+), ROS and phospholipase A(2), in particular iPLA(2), are thought to potentiate each other in positive feedback loops. NADP...

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Detalles Bibliográficos
Autores principales: Ismail, Hesham M., Scapozza, Leonardo, Ruegg, Urs T., Dorchies, Olivier M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201587/
https://www.ncbi.nlm.nih.gov/pubmed/25329652
http://dx.doi.org/10.1371/journal.pone.0110708

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201587/
https://www.ncbi.nlm.nih.gov/pubmed/25329652
http://dx.doi.org/10.1371/journal.pone.0110708

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