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Diapocynin, a Dimer of the NADPH Oxidase Inhibitor Apocynin, Reduces ROS Production and Prevents Force Loss in Eccentrically Contracting Dystrophic Muscle
Elevation of intracellular Ca(2+), excessive ROS production and increased phospholipase A(2) activity contribute to the pathology in dystrophin-deficient muscle. Moreover, Ca(2+), ROS and phospholipase A(2), in particular iPLA(2), are thought to potentiate each other in positive feedback loops. NADP...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201587/ https://www.ncbi.nlm.nih.gov/pubmed/25329652 http://dx.doi.org/10.1371/journal.pone.0110708 |