Subcellular transcriptome alterations in a cell culture model of spinal muscular atrophy point to widespread defects in axonal growth and presynaptic differentiation

Neuronal function critically depends on coordinated subcellular distribution of mRNAs. Disturbed mRNA processing and axonal transport has been found in spinal muscular atrophy and could be causative for dysfunction and degeneration of motoneurons. Despite the advances made in characterizing the tran...

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Detalles Bibliográficos
Autores principales: Saal, Lena, Briese, Michael, Kneitz, Susanne, Glinka, Michael, Sendtner, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201830/
https://www.ncbi.nlm.nih.gov/pubmed/25246652
http://dx.doi.org/10.1261/rna.047373.114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201830/
https://www.ncbi.nlm.nih.gov/pubmed/25246652
http://dx.doi.org/10.1261/rna.047373.114

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